AUTHOR=Liu Xinyuan , Dun Mengqian , Jian Tongtong , Sun Yuqing , Wang Mingyu , Zhang Guoying , Ling Jianya 

TITLE=Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1134429

DOI=10.3389/fphar.2023.1134429

ISSN=1663-9812

ABSTRACT=<p><bold>Introduction:</bold><italic>Cordyceps militaris</italic>, which has many potential medicinal properties, has rarely been reported to alleviate type 2 diabetes mellitus (T2DM).</p><p><bold>Methods:</bold> The effects of <italic>C. militaris</italic> extracts (CE) and cordycepin (CCS) on high-fat diet and streptozotocin (STZ) induced T2DM mice were analysed by gut microbiome and metabolomics methods in this study.</p><p><bold>Results:</bold> The results demonstrated that glucose and lipid metabolism parameters, oxidative stress biomarkers and inflammation cytokines were down-regulated in the CCS and CE groups. A comparative analysis of the fecal samples from mice in the model and experimental groups showed that experimental groups resulted in a higher abundance of Firmicutes/Bacteroidetes.</p><p><bold>Conclusion:</bold> This study provides evidence that <italic>C. militaris</italic> can be used as a food supplement to relieve T2DM, which provides a promising prospect for new functional food in it.</p>