AUTHOR=Ha Na-Yeon , Lee Hanul , Jeong Haein , Ko Seok-Jae , Park Jae-Woo , Kim Jinsung 

TITLE=Safety and efficacy of Xiaoyao-san for the treatment of functional dyspepsia: a systematic review and meta-analysis of randomized controlled trials

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1114222

DOI=10.3389/fphar.2023.1114222

ISSN=1663-9812

ABSTRACT=<p><bold>Objective:</bold> Although <italic>Xiaoyao-san</italic> (XYS) is a popular herbal remedy for indigestion, there is insufficient evidence to recommend it as a treatment option for functional dyspepsia (FD). This review aimed to assess the safety and efficacy of XYS in patients with FD, compared to conventional Western medicine (WM).</p><p><bold>Methods:</bold> Two independent reviewers searched for randomized controlled trials (RCTs) using 11 electronic databases, including Medline and Embase, to evaluate therapeutic effects of XYS on FD up to 31 January 2023. The primary outcome was the total clinical efficacy rate (TCE), and secondary outcomes included scores of dyspepsia-related symptoms (DSS) and incidence of adverse events (AEs). The risk of bias was evaluated using the Cochrane collaboration tool, and data synthesis and subgroup analyses were performed using the Review Manager program.</p><p><bold>Results:</bold> Six studies involving 707 participants were included in the meta-analysis. XYS significantly improved TCE compared to WM (RR = 1.15, 95% CI: 1.05, 1.26, <italic>p</italic> = 0.002) with high heterogeneity (<italic>I</italic><sup><italic>2</italic></sup> = 59%, <italic>p</italic> = 0.06). Combination therapy also showed higher TCE than WM alone (RR = 1.22, 95% CI: 1.05, 1.41, <italic>p</italic> = 0.008), and the heterogeneity was low (<italic>I</italic><sup><italic>2</italic></sup> = 0%, <italic>p</italic> = 0.86). The results showed a greater reduction in DSS in the XYS and combination therapy groups than in the WM alone group (SMD = −0.72, 95% CI: −0.90, −0.53, <italic>p</italic> &lt; 0.00001) with low heterogeneity (<italic>I</italic><sup><italic>2</italic></sup> = 44%, <italic>p</italic> = 0.15), especially for abdominal distension and upper abdominal pain. AEs occurred less frequently in the XYS and combination therapy groups than in the WM alone group (RR = 0.20, 95% CI: 0.07, 0.63, <italic>p</italic> = 0.006), and the heterogeneity was low (<italic>I</italic><sup><italic>2</italic></sup> = 45%, <italic>p</italic> = 0.18). The certainty of the evidence for each outcome was rated from “very low” to “high.”</p><p><bold>Conclusion:</bold> This review suggests that XYS is effective and safe for reducing complaints in patients with FD. However, high-quality RCTs should be conducted to establish more convincing therapeutic evidence of XYS for the treatment of FD.</p><p><bold>Systematic Review Registration:</bold><ext-link ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/prospero" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.crd.york.ac.uk/prospero</ext-link>, CRD42020178842</p>