AUTHOR=Qin Manman , Qian Yuqing , Huang Lu , Zhong Chao , Li Mingdong , Yu Jun , Chen Huanwen TITLE=Extractive electrospray ionization mass spectrometry for analytical evaluation and synthetic preparation of pharmaceutical chemicals JOURNAL=Frontiers in Pharmacology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1110900 DOI=10.3389/fphar.2023.1110900 ISSN=1663-9812 ABSTRACT=

Extraction electrospray ionization mass spectrometry (EESI-MS), due to the unique configuration of its ionization module, enables the effective ionization of trace molecules of interest in samples containing complex matrices with high sensitivity, high selectivity and high responding speed without requiring sample pretreatment, and allows high-energy molecular species to undergo specially designed reactions for advanced functionalization. The typical effects of operating conditions on the analytical performance of extraction electrospray ionization mass spectrometry for various pharmaceutical compounds, pharmaceutical preparations and herbal materials were systematically reviewed. The application prospect of extraction electrospray ionization in molecular functionalization for advanced drug discovery is also briefly introduced.