AUTHOR=Huang Wei , Rao Yanling , Li Liang , Li Chengyin , An Yi 

TITLE=Clinical effect of rhubarb on the treatment of chronic renal failure: A meta-analysis

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1108861

DOI=10.3389/fphar.2023.1108861

ISSN=1663-9812

ABSTRACT=<p><bold>Objective:</bold> 1) To evaluate the effificacy of <italic>rhubarb</italic> in the treatment of chronic renal failure (CRF); 2) To explore the safety for rhubarb-based therapy on chronic renal failure.</p><p><bold>Methods:</bold> The randomized and semi randomized controlled trials of <italic>Rhubarb</italic> in the treatment of chronic renal failure in medical electronic databases (up to September 2021) were searched, and meta-analysis was carried out by revman 5.3 software.</p><p><bold>Results:</bold> A total of 2,786 patients were included in 34 literatures, including 1,474 cases in the treatment group and 1,312 cases in the control group. The results of meta-analysis showed that Serum creatinine (SCR) [MD = 123.57, 95% Cl (111.59, 131.96)], Blood urea nitrogen (BUN) [MD = −3.26, 95% Cl (−4.22,−2.31)], Creatinine clearance rate (CCR) [MD = 3.95, 95% Cl (−0.03, 7.93)], Hemoglobin (Hb) [MD = 7.70, 95% Cl (−0.18, 15.58)] and Uric acid (UA) [MD = −42.79, 95% CI (−66.29, −19.29)]. The total effective rate of improving symptoms and signs in chronic renal failure patients [Peto or = 4.14, 95% Cl (3.32, 5.16)].</p><p><bold>Conclusion:</bold> This systematic review and meta-analysis demonstrated that rhubarb has a positive therapeutic effect, which may provide confifidence and some theoretical reference for clinical application to a certain extent. Compared with the control group, <italic>rhubarb</italic> alone or traditional Chinese medicine compound containing <italic>Rhubarb</italic> can significantly reduce Serum creatinine, Blood urea nitrogen and Uric acid, increase Creatinine clearance rate, and improve the total effective rate of symptoms and signs. However, there is no evidence that <italic>rhubarb</italic> is more effective than the control group in increasing hemoglobin. In addition, due to the low quality of research methodology in the included literature, it is necessary to further study high-quality literature to evaluate its efficacy and safety.</p><p><bold>Systematic Review Registration:</bold><ext-link ext-link-type="uri" xlink:href="https://inplasy.com/inplasy-2021-10-0052/" xmlns:xlink="http://www.w3.org/1999/xlink">https://inplasy.com/inplasy-2021-10-0052/</ext-link>, identifier INPLASY2021100052.</p>