AUTHOR=Suemanotham Namphung , Phochantachinda Sataporn , Chatchaisak Duangthip , Sakcamduang Walasinee , Chansawhang Anchana , Pitchakarn Pornsiri , Chantong Boonrat 

TITLE=Antidiabetic effects of Andrographis paniculata supplementation on biochemical parameters, inflammatory responses, and oxidative stress in canine diabetes

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1077228

DOI=10.3389/fphar.2023.1077228

ISSN=1663-9812

ABSTRACT=<p><bold>Introduction:</bold> Diabetes mellitus is a common endocrine disorder that causes hyperglycemia in dogs. Persistent hyperglycemia can induce inflammation and oxidative stress. This study aimed to investigate the effects of <italic>A. paniculata</italic> (Burm.f.) Nees (Acanthaceae) (<italic>A. paniculata</italic>) on blood glucose, inflammation, and oxidative stress in canine diabetes. A total of 41 client-owned dogs (23 diabetic and 18 clinically healthy) were included in this double-blind, placebo-controlled trial.</p><p><bold>Methods:</bold> The diabetic dogs were further divided into two treatments protocols: group 1 received <italic>A. paniculata</italic> extract capsules (50 mg/kg/day; <italic>n</italic> = 6) or received placebo for 90 days (<italic>n</italic> = 7); and group 2 received <italic>A. paniculata</italic> extract capsules (100 mg/kg/day; <italic>n</italic> = 6) or received a placebo for 180 days (<italic>n</italic> = 4). Blood and urine samples were collected every month. No significant differences in fasting blood glucose, fructosamine, interleukin-6, tumor necrosis factor-alpha, superoxide dismutase, and malondialdehyde levels were observed between the treatment and placebo groups (<italic>p</italic> &gt; 0.05).</p><p><bold>Results and Discussion:</bold> The levels of alanine aminotransferase, alkaline phosphatase, blood urea nitrogen, and creatinine were stable in the treatment groups. The blood glucose levels and concentrations of inflammatory and oxidative stress markers in the client-owned diabetic dogs were not altered by <italic>A. paniculata</italic> supplementation. Furthermore, treatment with this extract did not have any adverse effects on the animals. Non-etheless, the effects of <italic>A. paniculata</italic> on canine diabetes must be appropriately evaluated using a proteomic approach and involving a wider variety of protein markers.</p>