AUTHOR=Yin Xiaoying , Yin Xinxin , Pan Xin , Zhang Jingyu , Fan Xinhui , Li Jiaxin , Zhai Xiaoxuan , Jiang Lijun , Hao Panpan , Wang Jiali , Chen Yuguo 

TITLE=Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1070973

DOI=10.3389/fphar.2023.1070973

ISSN=1663-9812

ABSTRACT=<p>Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signaling pathways and various types of cells in time-dependent manners. Our understanding of the development of cardiac fibrosis after MI has evolved in basic and clinical researches, and the regulation of fibrotic remodeling may facilitate novel diagnostic and therapeutic strategies, and finally improve outcomes. Here, we aim to elaborate pathophysiology, examination and intervention of cardiac fibrosis after MI.</p>