AUTHOR=Song Yuanbin , Chen Shuzhao , Liu Chenfei , Chen Lezong , Wang Weida , Wu Bingyi , Liang Yang 

TITLE=Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1051305

DOI=10.3389/fphar.2023.1051305

ISSN=1663-9812

ABSTRACT=<p>Maintenance therapy in adult T-cell acute lymphoblastic leukemia (T-ALL) is the longest phase but with limited option. The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. Optimizing therapy in the modern age, chemo-free maintenance therapy regimens for patients with T-ALL may dramatically improve the maintenance therapeutic landscape. We report here the combination of Anti-programmed cell death protein 1 antibody and histone deacetylase inhibitor as chemo-free maintenance treatment in a T-ALL patient with literature review, thus providing a unique perspective in addition to valuable information which may inform novel therapeutic approaches.</p>