AUTHOR=Chen Zeyu , Huang Yin , Cao Dehong , Qiu Shi , Chen Bo , Li Jin , Bao Yige , Wei Qiang , Han Ping , Liu Liangren 

TITLE=Function of sildenafil on diseases other than urogenital system: An umbrella review

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1033492

DOI=10.3389/fphar.2023.1033492

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold> To investigate the function of sildenafil on diseases other than urogenital system, an umbrella review was conducted.</p><p><bold>Methods:</bold> Meta-analysis and systematic reviews on this topic were comprehensively evaluated in this umbrella review. Quality of evidence was evaluated through AMSTAR and the Grading of Recommendations, Assessment, Development and Evaluation system to generate a reliable and valid conclusion.</p><p><bold>Results:</bold> 77 out of 1164 meta-analysis were enrolled. 33 significant outcomes and 41 non-significant outcomes were extracted from all eligible articles. We found sildenafil did significant help in reducing arterial systolic pressure, mean pulmonary arterial pressure, pulmonary arterial pressure, systolic pulmonary arterial pressure in patients with pulmonary and cardiovascular diseases. Besides, sildenafil also improved exercise capacity or performance in patients with pulmonary and cardiovascular diseases. Other than these patients, this drug contributed great help in pregnant women with fetal growth restriction and preeclampsia by increasing the weight of newborns and lowering uterine and umbilical pulsatility indices. Additionally, it was reported that utilization of sildenafil has brought increased risk of melanoma.</p><p><bold>Conclusion:</bold> We can conclude from our study that sildenafil played an important role in many fields, especially in vascular protection. This finding provides a strong evidence for further expansion of sildenafil utilization in other diseases.</p>