AUTHOR=Zhang Yuxin , Zhang Wenzhou , Zheng Lufeng , Guo Qianqian TITLE=The roles and targeting options of TRIM family proteins in tumor JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.999380 DOI=10.3389/fphar.2022.999380 ISSN=1663-9812 ABSTRACT=
Tripartite motif (TRIM) containing proteins are a class of E3 ubiquitin ligases, which are critically implicated in the occurrence and development of tumors. They can function through regulating various aspects of tumors, such as tumor proliferation, metastasis, apoptosis and the development of drug resistance during tumor therapy. Some members of TRIM family proteins can mediate protein ubiquitination and chromosome translocation