AUTHOR=Yoshimura Takuya , Suzuki Hajime , Takayama Hirotaka , Higashi Shotaro , Hirano Yuka , Tezuka Masahiro , Ishida Takayuki , Ishihata Kiyohide , Amitani Marie , Amitani Haruka , Nishi Yasuhiro , Nakamura Yasunori , Imamura Yasushi , Nozoe Etsuro , Inui Akio , Nakamura Norifumi 

TITLE=Prognostic value of inflammatory biomarkers in aged patients with oral squamous cell carcinoma

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.996757

DOI=10.3389/fphar.2022.996757

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold> Better prognostic biomarkers for oral squamous cell carcinoma (OSCC) must be developed, particularly within the realm of clinically and frequently administered tests, to advise appropriate clinical therapy and follow-up. In this study, we retrospectively investigated which of the several inflammation-nutrition indicators might predict the prognosis of patients with OSCC.</p><p><bold>Methods:</bold>  The preoperative neutrophil-lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), platelet–lymphocyte ratio (PLR), CRP-albumin ratio (CAR), Glasgow prognostic score (GPS), modified GPS (mGPS), prognostic nutritional index (PNI), controlling nutrition status (CONUT), and modified CONUT (mCONUT) were retrospectively evaluated using blood samples collected 1–5 days before surgery. To estimate the effect on the prognosis of tumor progression, the mean values of the markers between stages I/II and III/IV were used for subgroup analysis. The multivariate Cox proportional hazards model included all independent variables significantly associated with survival in the univariate analysis to determine the independent variables.</p><p><bold>Results:</bold> A total of 112 patients (69 males and 43 females) with primary OSCC who underwent surgical treatment at our hospital were included. There were statistically significant differences in the mean values of monocytes, platelets, and albumin between stages I/II and III/IV. According to the multivariate Cox proportional hazards regression, a low PNI was associated with shorter overall survival (OS) and disease-free survival (DFS); women were associated with shorter DFS.</p><p><bold>Conclusion:</bold> The pretreatment PNI had excellent predictive value for the 5-year OS and DFS of patients with OSCC. Future large-scale prospective studies with a high sample size are needed to verify our findings in OSCC patients.</p>