AUTHOR=Wu Fan , Tian Mei , Sun Yuefeng , Wu Changhao , Liu Xue 

TITLE=Efficacy, chemical composition, and pharmacological effects of herbal drugs derived from Fritillaria cirrhosa D. Don and Fritillaria thunbergii Miq.

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.985935

DOI=10.3389/fphar.2022.985935

ISSN=1663-9812

ABSTRACT=<p><italic>Fritillaria cirrhosa</italic> D. Don and <italic>F. thunbergii</italic> Miq. belong to the genus <italic>Fritillaria</italic> within the Liliaceae family. They are used in traditional Chinese medicines that are often administered in clinical settings as they have notable effects on cough, bronchitis, pneumonia, lung injury, cancer, and other diseases. In this review, we focus on the history, origin, similarities, and differences in efficacy, chemical composition, and pharmacological outcomes of the drugs obtained from <italic>F. cirrhosa</italic> (FRC) and <italic>F. thunbergii</italic> (FRT). We list various valuable pharmacological effects of FRC and FRT, including antitussive, expectorant, anti-inflammatory, antioxidant, and anticancer effects. Thus, this review offers a basis for the medical application of and further research into the pharmacological impacts of these two drugs. We believe that new drugs derived from the phytoconstituents of <italic>F. cirrhosa</italic> and <italic>F. thunbergii</italic> that have specific therapeutic properties can be developed in the future.</p>