AUTHOR=Wang Hang , Dong Xianghuan , Awan Maher Un Nisa , Bai Jie 

TITLE=Epigenetic mechanisms involved in methamphetamine addiction

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.984997

DOI=10.3389/fphar.2022.984997

ISSN=1663-9812

ABSTRACT=<p>Methamphetamine (METH) is an illicit psychostimulant that is widely abused. The molecular mechanism of METH addiction is complicated and still unknown. METH causes the release of the neurotransmitters including dopamine, glutamate, norepinephrine and serotonin, which activate various brain areas in the central nervous system. METH also induces synaptic plasticity and pathological memory enhancement. Epigenetics plays the important roles in regulating METH addiction. This review will briefly summarize the studies on epigenetics involved in METH addiction.</p>