AUTHOR=Li Qiaoyu , Wang Mengchen , Zhang Shuxia , Jin Meiqi , Chen Rongchang , Luo Yun , Sun Xiaobo TITLE=Single-cell RNA sequencing in atherosclerosis: Mechanism and precision medicine JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.977490 DOI=10.3389/fphar.2022.977490 ISSN=1663-9812 ABSTRACT=

Atherosclerosis is the pathological basis of various vascular diseases, including those with high mortality, such as myocardial infarction and stroke. However, its pathogenesis is complex and has not been fully elucidated yet. Over the past few years, single-cell RNA sequencing (scRNA-seq) has been developed and widely used in many biological fields to reveal biological mechanisms at the cellular level and solve the problems of cellular heterogeneity that cannot be solved using bulk RNA sequencing. In this review, we briefly summarize the existing scRNA-seq technologies and focus on their application in atherosclerosis research to provide insights into the occurrence, development and treatment of atherosclerosis.