AUTHOR=Bervinova Arina V. , Palikov Viktor A. , Mikhailov Evgeny S. , Palikova Yulia A. , Borozdina Natalya A. , Kazakov Vitaly A. , Rudenko Pavel A. , Tukhovskaya Elena A. , Dyachenko Igor A. , Slashcheva Gulsara A. , Goryacheva Natalya A. , Sadovnikova Elena S. , Kravchenko Irina N. , Kalabina Elena A. , Shinelev Maksim V. , Wu Peng , Murashev Arkady N. 

TITLE=Efficacy of Ficus tikoua Bur. extract in ethylene glycol-induced urolithiasis model in SD rats

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.974947

DOI=10.3389/fphar.2022.974947

ISSN=1663-9812

ABSTRACT=<p>The development of new herbal preparations for the treatment of urolithiasis is an urgent task of medical science. Ficus have attracted the attention of pharmacologists due to a wide range of biological properties, including antioxidant, anti-inflammatory, antibacterial and antifungal activity. We studied the effectiveness of <italic>Ficus tikoua</italic> Bur. in SD rats in which urolithiasis was induced by 6 weeks of oral administration of ethylene glycol 0.5% <italic>ad libitum</italic> instead of drinking water. Administration of the extract of <italic>Ficus tikoua</italic> Bur., as well as comparative drug Cystone<sup>®</sup> after modeling of urolithiasis lead to the restoration of diuresis and the concentration of inorganic phosphates starting from the 6th week of the experiment. The use of the <italic>Ficus tikoua</italic> Bur. extract for 6 weeks, both during the modeling of urolithiasis and during the recovery period, led to the restoration of the percentage of lymphocytes in the blood, content of sodium, chlorine and inorganic phosphates in the blood to the control level. Thus, the extract of <italic>Ficus tikoua</italic> Bur. seems to be a promising drug for effective treatment of the initial stages of the development of urolithiasis.</p>