AUTHOR=Yuan Huimin , Sun Yan , Zhang Shujing , Feng Jing , Tian Zijiao , Liu Jingang , Wang Hang , Gao Yushan , Tang Yang , Zheng Fengjie 

TITLE=NLRP3 neuroinflammatory factors may be involved in atopic dermatitis mental disorders: an animal study

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.966279

DOI=10.3389/fphar.2022.966279

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold> Numerous clinical studies have shown that atopic dermatitis (AD) is often associated with mental disorders. This could contribute to the overall burden of atopic dermatitis. However, the underlying mechanism of mental health symptoms in AD has not been fully elucidated.</p><p><bold>Methods:</bold> An AD mouse was induced by 2,4-dinitrofluorobenzene (DNFB), which was repeatedly applied to the back skin of the BALB/C mice to establish an atopic dermatitis mental disorder model. The role of neuroinflammation in the pathogenesis of atopic dermatitis mental disorders was then explored.</p><p><bold>Results:</bold> After the stimulation of DNFB for 35 days, the skin lesions, the HE staining of skin lesions, and the behavioral experiments (including elevated plus maze assay and tail suspension test) suggested that the AD mental disorder mouse model was successfully replicated. The expression of neuroinflammatory factors in the hippocampus was then investigated through Western blotting. The results showed a significant increase in the protein expression of NLRP3, caspase-1, and IL-1β.</p><p><bold>Conclusion:</bold> Mental disorders in AD might be related to the neuroinflammatory response in the hippocampus. An alternative yet essential approach to promoting AD recovery could be through reducing neuroinflammation and improving mental disorders.</p>