AUTHOR=Yin Yi , Han Xing , Li Cheng , Sun Tonghui , Li Kailin , Liu Xionghao , Liu Mujun 

TITLE=The status of industrialization and development of exosomes as a drug delivery system: A review

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.961127

DOI=10.3389/fphar.2022.961127

ISSN=1663-9812

ABSTRACT=<p>Exosomes, as natural biomolecular carriers produced by cells, have the potential and advantage of delivering drugs to target organs or cells <italic>in vivo</italic>. The steps to improve exosomes as a drug delivery system can be divided into three steps:large-scale preparation of exosomes, loading of drugs and targeted delivery of exosomes. Based on the existing production process and technology, there is still much room for improvement. This review highlights the research progress in three aspects and proposes new technologies and innovative approaches to improve the efficiency of exosome delivery.</p>