AUTHOR=Norouzkhani Narges , Karimi Arian Ghannadi , Badami Negar , Jalalifar Erfan , Mahmoudvand Behnaz , Ansari Arina , Pakrou Sariyarighan Neda , Alijanzadeh Dorsa , Aghakhani Sara , Shayestehmehr Reza , Arzaghi Mohammadreza , Sheikh Zahra , Salami Yasaman , Marabi Mohammad Hesam , Abdi Amir , Deravi Niloofar 

TITLE=From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.960037

DOI=10.3389/fphar.2022.960037

ISSN=1663-9812

ABSTRACT=<p>Aging is described as an advanced time-related collection of changes that may negatively affect with the risk of several diseases or death. Aging is a main factor of several age-related neurological disorders, including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, and dementia), stroke, neuroinflammation, neurotoxicity, brain tumors, oxidative stress, and reactive oxygen species (ROS). Currently available medications for age-related neurological disorders may lead to several side effects, such as headache, diarrhea, nausea, gastrointestinal (GI) diseases, dyskinesia, and hallucinosis. These days, studies on plant efficacy in traditional medicine are being conducted because herbal medicine is affordable, safe, and culturally acceptable and easily accessible. The Indian traditional medicine system called Ayurveda uses several herbs and medicinal plants to treat various disorders including neurological disorders. This review aims to summarize the data on the neuroprotective potential of the following common Indian spices widely used in Ayurveda: cumin (<italic>Cuminum cyminum</italic> (L.), Apiaceae), black cumin (<italic>Nigella sativa</italic> (L.), Ranunculaceae), black pepper (<italic>Piper nigrum</italic> (L.), Piperaceae), curry leaf tree (<italic>Murraya koenigii</italic> (L.), Spreng Rutaceae), fenugreek (<italic>Trigonella foenum-graecum</italic> (L.), Fabaceae), fennel (<italic>Foeniculum vulgare</italic> Mill, Apiaceae), cardamom (<italic>Elettaria cardamomum</italic> (L.) Maton, Zingiberaceae), cloves (<italic>Syzygium aromaticum</italic> (L.) Merr. &amp; L.M.Perry, Myrtaceae), and coriander (<italic>Coriandrum sativum</italic> (L.), Apiaceae) in age-related neurological disorders.</p>