AUTHOR=Ferreira Jacob , Levin Lonny R. , Buck Jochen 

TITLE=Strategies to safely target widely expressed soluble adenylyl cyclase for contraception

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.953903

DOI=10.3389/fphar.2022.953903

ISSN=1663-9812

ABSTRACT=<p>In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception.</p>