AUTHOR=Matouk Asmaa I. , El-Daly Mahmoud , Habib Heba A. , Senousy Shaymaa , Naguib Abdel Hafez Sara Mohamed , Kasem AlShaimaa W. , Almalki Waleed Hassan , Alzahrani Abdulaziz , Alshehri Ahmed , Ahmed Al-Shaimaa F. TITLE=Protective effects of menthol against sepsis-induced hepatic injury: Role of mediators of hepatic inflammation, apoptosis, and regeneration JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.952337 DOI=10.3389/fphar.2022.952337 ISSN=1663-9812 ABSTRACT=
Liver dysfunction in sepsis is a major complication that amplifies multiple organ failure and increases the risk of death. Inflammation and oxidative stress are the main mediators in the pathophysiology of sepsis. Therefore, we investigated the role of menthol, a natural antioxidant, against sepsis-induced liver injury in female Wistar rats. Sepsis was induced by cecal ligation and puncture (CLP). Menthol (100 mg/kg) was given intragastric 2 h after CLP. Blood samples and liver tissues were collected 24 h after surgery. Menthol significantly (