AUTHOR=Wang Shuai , Luo Sean X. , Jie Jing , Li Dan , Liu Han , Song Lei 

TITLE=Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.946554

DOI=10.3389/fphar.2022.946554

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold> The clinical efficiency of terpenoids in treating human acute lung injury (ALI) is yet to be determined. The lipopolysaccharide-induced rat model of ALI is a well-established and widely used experimental model for studying terpenoids’ effects on ALI. Using a systematic review and meta-analysis, the therapeutic efficiency of terpenoid administration on the lung wet-to-dry weight ratio in rats was investigated.</p><p><bold>Methods:</bold> Using the Cochrane Library, Embase, and PubMed databases, a comprehensive literature search for studies evaluating the therapeutic efficacy of terpenoids on ALI in rats was conducted. The lung wet-to-dry weight ratio was extracted as the main outcome. The quality of the included studies was assessed using the Systematic Review Center for Laboratory Animal Experimentation’s risk of bias tool.</p><p><bold>Results:</bold> In total, 16 studies were included in this meta-analysis. In general, terpenoids significantly lowered the lung wet-to-dry weight ratio when compared with the control vehicle (<italic>p</italic> = 0.0002; standardized mean difference (SMD): −0.16; 95% confidence interval (CI): −0.24, −0.08). Subgroup analysis revealed that low dose (≤10 μmol/kg) (<italic>p &lt;</italic> 0.0001; SMD: −0.68; 95% CI: −1.02, −0.34), intraperitoneal injection (<italic>p</italic> = 0.0002; SMD: −0.43; 95% CI: −0.66, −0.20), diterpenoid (<italic>p</italic> = 0.004; SMD: −0.13; 95% CI: −0.23, −0.04), and triterpenoid (<italic>p</italic> = 0.04; SMD: −0.28; 95% CI: −0.54, −0.01) significantly lowered the lung wet-to-dry weight ratio when compared with the control vehicle.</p><p><bold>Conclusion:</bold> A low dose of diterpenoid and triterpenoid administered intraperitoneally is effective in alleviating ALI. This systematic review and meta-analysis provides a valuable mirror for clinical research aiming at the advancement of terpenoids for preventive and therapeutic use.</p><p><bold>Systematic Review Registration:</bold> CRD42022326779</p>