AUTHOR=Yang Shaojie , Dai Wanlin , Wang Jingnan , Zhang Xiaolin , Zheng Yuting , Bi Shiyuan , Pang Liwei , Ren Tengqi , Yang Ye , Sun Yang , Zheng Zhuyuan , Wu Shuodong , Kong Jing TITLE=Osthole: An up-to-date review of its anticancer potential and mechanisms of action JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.945627 DOI=10.3389/fphar.2022.945627 ISSN=1663-9812 ABSTRACT=

With its high incidence and mortality rates, cancer is one of the largest health problems worldwide. Investigating various cancer treatment options has been the focus of many domestic and international researchers, and significant progress has been made in the study of the anticancer effects of traditional Chinese medicines. Osthole, a coumarin compound extracted from Cnidium monnieri (L.) Cuss., has become a new research hotspot. There have been many reports on its anticancer effects, and recent studies have elucidated that its underlying mechanism of action mainly involves inhibiting cancer cell proliferation, inducing cancer cell apoptosis, inhibiting invasion and migration of cancer cells, inhibiting cancer angiogenesis, increasing sensitivity to chemotherapy drugs, and reversing multidrug resistance of cancer cells. This mini-review summarizes the research progress on the anticancer effects of osthole in recent years.