AUTHOR=Kardas Przemysław , Bago Martina , Barnestein-Fonseca Pilar , Garuolienė Kristina , Granas Anne Gerd , Gregório João , Hadžiabdić Maja Ortner , Kostalova Barbora , Leiva-Fernández Francisca , Lewek Pawel , Mala-Ladova Katerina , Schneider Marie Paule , van Boven Job F. M. , Volmer Daisy , Ziampara Ioli , Ágh Tamás TITLE=Reimbursed medication adherence enhancing interventions in 12 european countries: Current state of the art and future challenges JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.944829 DOI=10.3389/fphar.2022.944829 ISSN=1663-9812 ABSTRACT=

Background: Medication non-adherence jeopardises the effectiveness of chronic therapies and negatively affects financial sustainability of healthcare systems. Available medication adherence-enhancing interventions (MAEIs) are utilised infrequently, and even more rarely reimbursed. The aim of this paper was to review reimbursed MAEIs across selected European countries.

Methods: Data on reimbursed MAEIs were collected from European countries at the ENABLE Cost Action expert meeting in September 2021. The identified MAEIs were analysed and clustered according to their characteristics, direct vs. indirect relation to adherence, and the targeted adherence phase.

Results: Out of 12 contributing countries, 10 reported reimbursed MAEIs, 28 in total, of which 20 were identified as MAEIs targeting adherence directly. Reimbursed MAEIs were most often performed by either doctors (n = 6), nurses (n = 6), or pharmacists (n = 3). The most common types of MAEIs were education (n = 6), medication regimen management (n = 5), and adherence monitoring feedback (n = 4). Only seven reimbursed MAEIs were technology-mediated, whereas 11 addressed two interlinked phases of medication adherence, i.e., implementation and persistence.

Conclusion: Our review highlights the scarcity of reimbursed MAEIs across the selected European countries, and calls for their more frequent use and reimbursement.