AUTHOR=Wang Chang-Lin , Gao Ming-Zhou , Gao Dong-Mei , Guo Ying-Hui , Gao Zhan , Gao Xiang-Ju , Wang Jie-Qiong , Qiao Ming-Qi TITLE=Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.941270 DOI=10.3389/fphar.2022.941270 ISSN=1663-9812 ABSTRACT=
Tubeimoside-1 (TBMS-1), a natural triterpenoid saponin found in traditional Chinese herbal medicine Bolbostemmatis Rhizoma, is present in numerous Chinese medicine preparations. This review aims to comprehensively describe the pharmacology, pharmacokinetics, toxicity and targeting preparations of TBMS-1, as well the therapeutic potential for cancer treatement. Information concerning TBMS-1 was systematically collected from the authoritative internet database of PubMed, Web of Science, and China National Knowledge Infrastructure applying a combination of keywords involving “tumor,” “pharmacokinetics,” “toxicology,” and targeting preparations. New evidence shows that TBMS-1 possesses a remarkable inhibitory effect on the tumors of the respiratory system, digestive system, nervous system, genital system as well as other systems