AUTHOR=Zhong Shiyu , Shengyu Liu , Xin Shi , Zhang Xudong , Li Kunhang , Liu Guojun , Li Lishuai , Tao Shanwei , Zheng Bowen , Sheng Weichen , Ye Ziyin , Xing Qichen , Zhai Qingqing , Ren Lijie , Wu Ying , Bao Yijun TITLE=Disulfiram in glioma: Literature review of drug repurposing JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.933655 DOI=10.3389/fphar.2022.933655 ISSN=1663-9812 ABSTRACT=

Gliomas are the most common malignant brain tumors. High-grade gliomas, represented by glioblastoma multiforme (GBM), have a poor prognosis and are prone to recurrence. The standard treatment strategy is tumor removal combined with radiotherapy and chemotherapy, such as temozolomide (TMZ). However, even after conventional treatment, they still have a high recurrence rate, resulting in an increasing demand for effective anti-glioma drugs. Drug repurposing is a method of reusing drugs that have already been widely approved for new indication. It has the advantages of reduced research cost, safety, and increased efficiency. Disulfiram (DSF), originally approved for alcohol dependence, has been repurposed for adjuvant chemotherapy in glioma. This article reviews the drug repurposing method and the progress of research on disulfiram reuse for glioma treatment.