AUTHOR=Zaimović Majda Šahman , Kosović Perutović Milica , Jelušić Gordana , Radović Ana , Jaćimović Željko 

TITLE=The inhibitory effect of some pyrazole ligands and their Cu(II) complexes on the growth of Escherichia coli, Klebsiella–Enterobacter spp., and Staphylococcus aureus

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.921157

DOI=10.3389/fphar.2022.921157

ISSN=1663-9812

ABSTRACT=<p>The aim of this study was to evaluate the inhibitory activity of chemistry products against the growth of <italic>Escherichia coli</italic>, <italic>Klebsiella–Enterobacter</italic> spp., and <italic>Staphylococcus aureus</italic>. Pyrazole derivatives (4-bromo-2-(1H-pyrazol-3-yl)phenol, 4-nitro-3-pyrazolecarboxylic acid, N-(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine), 3-amino-5-hydroxypyrazole, 3,5-pyrazoledicarboxylic acid monohydrate, and selected complexes of Cu(II) with the mentioned pyrazoles as ligands were used as chemistry bioactives for antibacterial activity. The testing method was carried out according to the disc diffusion method. Some compounds have shown inhibitory effects against the growth of <italic>E. coli</italic>. A small number of compounds have shown inhibitory effects against the growth of <italic>Klebsiella–Enterobacter</italic> spp. but did not show inhibitory effects on <italic>Staphylococcus aureus</italic> compared to amoxicillin as a standard.</p>