AUTHOR=Liu Xiao-Yu , Qian Ling-Ling , Wang Ru-Xing 

TITLE=Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.911704

DOI=10.3389/fphar.2022.911704

ISSN=1663-9812

ABSTRACT=<p>Hydrogen sulfide (H<sub>2</sub>S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H<sub>2</sub>S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in H<sub>2</sub>S biogenesis has been reported in a variety of vascular diseases and H<sub>2</sub>S supplementation exerts effects of vasodilation. Accumulating evidence has shown vascular potassium channels activation is involved in H<sub>2</sub>S-induced vasodilation. This review aimed to summarize and discuss the role of H<sub>2</sub>S in the regulation of vascular tone, especially by interaction with different vascular potassium channels and the underlying mechanisms.</p>