AUTHOR=Al-Kuraishy Hayder M. , Al-Hussaniy Hany A. , Al-Gareeb Ali I. , Negm Walaa A. , El-Kadem Aya H. , Batiha Gaber El-Saber , N. Welson Nermeen , Mostafa-Hedeab Gomaa , Qasem Ahmed H , Conte-Junior Carlos Adam 

TITLE=Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.905828

DOI=10.3389/fphar.2022.905828

ISSN=1663-9812

ABSTRACT=<p>Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies. However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity. Therefore, the present study aimed to assess the cardioprotective effects of <italic>P. ginseng</italic> C. A. Mey, febuxostat, and their combination against DOX-induced cardiotoxicity. Thirty-five Sprague Dawley male rats were used in this study. The animals were randomly divided into five groups, with seven rats per group. The control group received normal saline, the induced group received DOX only, and the treated group received <italic>P. ginseng</italic>, febuxostat, and their combination before DOX treatment. Biomarkers of acute cardiac toxicity were assessed in each group. Results showed that treatment with the combination of febuxostat and <italic>P. ginseng</italic> before DOX led to a significant improvement in the biomarkers of acute DOX-induced cardiotoxicity. In conclusion, the combination of <italic>P. ginseng</italic> and febuxostat produced more significant cardioprotective effects against DOX-induced cardiotoxicity when compared to either <italic>P. ginseng</italic> or febuxostat when used alone. The potential mechanism of this combination was mainly mediated by the anti-inflammatory and antioxidant effects of <italic>P. ginseng</italic> and febuxostat.</p>