AUTHOR=Tang Jinxin , He Jieyu , Feng Chengyao , Tu Chao 

TITLE=Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.902049

DOI=10.3389/fphar.2022.902049

ISSN=1663-9812

ABSTRACT=<p>MiRNAs are a group of non-coding RNA molecules that function in mRNA translational inhibition <italic>via</italic> base-pairing with complementary sequences in target mRNA. In oncology, miRNAs have raised great attention due to their aberrant expression and pivotal roles in the pathogenesis of multiple malignancies including osteosarcoma. MiRNAs can be transported by exosome, the nano-extracellular vesicle with a diameter of 30–150 nm. Recently, a growing number of studies have demonstrated that exosomal miRNAs play a critical role in tumor initiation and progression, by exerting multiple biological functions including metastasis, angiogenesis, drug resistance and immunosuppression. In this review, we aim to depict the biogenesis of exosomal miRNAs and summarize the potential diagnostic and therapeutic functions of exosomal miRNAs in osteosarcoma.</p>