AUTHOR=Song Xiangqing , Wu Yi 

TITLE=Predicted Vancomycin Dosage Requirement in Patients With Hematological Malignancies and Dosage Dynamic Adjustment

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.890748

DOI=10.3389/fphar.2022.890748

ISSN=1663-9812

ABSTRACT=<p><bold>Purpose:</bold> The purpose of this study was 1) to predict the requisite vancomycin daily dose (<italic>D</italic><sub><italic>van</italic></sub>) used in the target patients suffering from both bacterial infection and hematological malignancies and 2) to construct a vancomycin-dose-graphical tool to assist clinicians to develop vancomycin dosing regimens and further 3) to establish a programming process for vancomycin dynamic dosage adjustment to help clinicians to adjust vancomycin dosing regimens according to physiological and pathogenic factors of the target patients.</p><p><bold>Methods:</bold> The <italic>D</italic><sub><italic>van</italic></sub> model associated with microbial susceptibility, vancomycin pharmacokinetics, and dosing parameters was established, and the <italic>D</italic><sub><italic>van</italic></sub> was estimated based on the established <italic>D</italic><sub><italic>van</italic></sub> model and using Monte Carlo simulations. <italic>D</italic><sub><italic>van</italic></sub> achieving 90% of probability of target attainment (PTA) for bacterial isolate or cumulative fractions of response (CFR) for the bacterial population at a ratio of daily area under the curve (AUC<sub>24</sub>) to the minimum inhibitory concentration (MIC) [i.e., AUC<sub>24</sub>/MIC] of 400–600 was considered sufficient to treat infection occurring in the target patients. On the basis of the predicted <italic>D</italic><sub><italic>van</italic></sub>, the physiological states of patients, and the pathogenic variables of infection, a vancomycin-dose-graphical tool for the target patients and a programming process for vancomycin dynamic dosage adjustment were constructed.</p><p><bold>Results:</bold> This study predicted the requisite <italic>D</italic><sub><italic>van</italic></sub> used in patients suffering from both bacterial infection and hematological malignancies and constructed a vancomycin-dose-graphical tool for the target patients, at different physiological states and pathogenic variables, to formulate vancomycin dosing regimens. Also, this study established and expounded the formulation process of vancomycin dosage dynamic adjustment according to fluctuant renal function of the target patients.</p><p><bold>Conclusion:</bold> With the tools, the required <italic>D</italic><sub><italic>van</italic></sub> or vancomycin dosing regimens for the target patients, at different physiological states and pathogenic variables, can be readily known, whether or not vancomycin dynamic dosage adjustment is required.</p>