AUTHOR=Tao Huaqiang , Tao Yunxia , Yang Chen , Li Wenming , Zhang Wei , Li Xueyan , Gu Ye , Hong Yujing , Yang Huilin , Liu Yu , Yang Xing , Geng Dechun 

TITLE=Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.875611

DOI=10.3389/fphar.2022.875611

ISSN=1663-9812

ABSTRACT=<title>Graphical Abstract</title><p>Uro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy. Uro-A upregulated the expression of Beclin 1 and LC3 and modulated bone homeostasis 4 in BMMs, thus resulting in decreased osteoclast-related markers and bone loss.<graphic xlink:href="FPHAR_fphar-2022-875611_wc_abs.tif" position="anchor" xmlns:xlink="http://www.w3.org/1999/xlink" /></p>