AUTHOR=Nishimura Yuhei , Kurosawa Kenji 

TITLE=Analysis of Gene-Environment Interactions Related to Developmental Disorders

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.863664

DOI=10.3389/fphar.2022.863664

ISSN=1663-9812

ABSTRACT=<p>Various genetic and environmental factors are associated with developmental disorders (DDs). It has been suggested that interaction between genetic and environmental factors (G <inline-formula id="inf1"><mml:math id="m1" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mo>×</mml:mo></mml:math></inline-formula> E) is involved in the etiology of DDs. There are two major approaches to analyze the interaction: genome-wide and candidate gene-based approaches. In this mini-review, we demonstrate how these approaches can be applied to reveal the G <inline-formula id="inf2"><mml:math id="m2" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mo>×</mml:mo></mml:math></inline-formula> E related to DDs focusing on zebrafish and mouse models. We also discuss novel approaches to analyze the G <inline-formula id="inf3"><mml:math id="m3" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mo>×</mml:mo></mml:math></inline-formula> E associated with DDs.</p>