AUTHOR=Mirazimi Seyed Mohammad Ali , Dashti Fatemeh , Tobeiha Mohammad , Shahini Ali , Jafari Raha , Khoddami Mehrad , Sheida Amir Hossein , EsnaAshari Parastoo , Aflatoonian Amir Hossein , Elikaii Fateme , Zakeri Melika Sadat , Hamblin Michael R , Aghajani Mohammad , Bavarsadkarimi Minoodokht , Mirzaei Hamed TITLE=Application of Quercetin in the Treatment of Gastrointestinal Cancers JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.860209 DOI=10.3389/fphar.2022.860209 ISSN=1663-9812 ABSTRACT=

Many cellular signaling pathways contribute to the regulation of cell proliferation, division, motility, and apoptosis. Deregulation of these pathways contributes to tumor cell initiation and tumor progression. Lately, significant attention has been focused on the use of natural products as a promising strategy in cancer treatment. Quercetin is a natural flavonol compound widely present in commonly consumed foods. Quercetin has shown significant inhibitory effects on tumor progression via various mechanisms of action. These include stimulating cell cycle arrest or/and apoptosis as well as its antioxidant properties. Herein, we summarize the therapeutic effects of quercetin in gastrointestinal cancers (pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral).