AUTHOR=Wang Bo , Shi Chao , Feng Lei , Pan Wei , Tian Xiang-Ge , Sun Cheng-Peng , Wang Chao , Ning Jing , Lv Xia , Wang Yan , Yuan Qian-Hui , Guan Rui-Xuan , Zhang Hou-Li , Ma Xiao-Chi , Ma Tong-Hui TITLE=Potent Inhibition of Human Cytochrome P450 3A4 by Biflavone Components from Ginkgo Biloba and Selaginella Tamariscina JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.856784 DOI=10.3389/fphar.2022.856784 ISSN=1663-9812 ABSTRACT=
CYP3A4-mediated Phase I biotransformation is the rate-limiting step of elimination for many commonly used clinically agents. The modulatory effects of herbal medicines on CYP3A4 activity are one of the risk factors affecting the safe use of drug and herbal medicine. In the present study, the inhibitory effects of nearly hundred kinds of herbal medicines against CYP3A4 were evaluated based on a visual high-throughput screening method. Furthermore, biflavone components including bilobetin (7-demethylginkgetin, DGK), ginkgetin (GK), isoginkgetin (IGK), and amentoflavone (AMF) were identified as the main inhibitory components of