AUTHOR=Zhang Juan , Xu Hong-Xi , Dou Yao-Xing , Huang Qiong-Hui , Xian Yan-Fang , Lin Zhi-Xiu 

TITLE=Major Constituents From Brucea javanica and Their Pharmacological Actions

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.853119

DOI=10.3389/fphar.2022.853119

ISSN=1663-9812

ABSTRACT=<p><italic>Brucea javanica</italic> (<italic>Ya-dan-zi</italic> in Chinese) is a well-known Chinese herbal medicine, which is traditionally used in Chinese medicine for the treatment of intestinal inflammation, diarrhea, malaria, and cancer. The formulation of the oil (<italic>Brucea javanica</italic> oil) has been widely used to treat various types of cancer. It has also been found that <italic>B. javanica</italic> is rich in chemical constituents, including quassinoids, triterpenes, alkaloids and flavonoids. Pharmacological studies have revealed that chemical compounds derived from <italic>B. javanica</italic> exhibit multiple bioactivities, such as anti-cancer, anti-bacterial, anti-diabetic, and others. This review provides a comprehensive summary on the pharmacological properties of the main chemical constituents presented in <italic>B. javanica</italic> and their underlying molecular mechanisms. Moreover, the review will also provide scientific references for further research and development of <italic>B. javanica</italic> and its chemical constituents into novel pharmaceutical products for disease management<italic>.</italic></p>