AUTHOR=Jiang Xinguo , Tian Wen , Kim Dongeon , McQuiston Alexander S. , Vinh Ryan , Rockson Stanley G. , Semenza Gregg L. , Nicolls Mark R. 

TITLE=Hypoxia and Hypoxia-Inducible Factors in Lymphedema

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.851057

DOI=10.3389/fphar.2022.851057

ISSN=1663-9812

ABSTRACT=<p>Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease. Hypoxia is a recognized feature of inflammation, obesity, and fibrosis. Understanding hypoxia-regulated pathways in lymphedema may provide new insights into the pathobiology of this chronic disorder and help develop new medicinal treatments.</p>