AUTHOR=Qin Jianru , Lin Jilei , Zhang Xiangfei , Yuan Shuhua , Zhang Chiyu , Yin Yong 

TITLE=Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.849545

DOI=10.3389/fphar.2022.849545

ISSN=1663-9812

ABSTRACT=<p><bold>Objective:</bold> To estimate the clinical effectiveness of oseltamivir in children with different subtypes of influenza virus infection.</p><p><bold>Methods:</bold> A total of 998 children with acute respiratory infection were enrolled from January to March 2018, and were divided into influenza A, influenza B, influenza A + B, and non-influenza infection (IV-negative) groups. Influenza-like symptoms and duration of fever were evaluated and compared between oseltamivir-treated and non-treated groups.</p><p><bold>Results:</bold> There were no significant differences in the reduction in total febrile period and duration of fever from the onset of therapy between the oseltamivir treated and non-treated children infected with influenza A (<italic>p</italic> = 0.6885 for total febrile period and 0.7904 for the duration of fever from the onset of treatment), influenza B (<italic>p</italic> = 0.1462 and 0.1966), influenza A + B (<italic>p</italic> = 0.5568 and 0.9320), and IV-negative (<italic>p</italic> = 0.7631 and 0.4655). The duration of fever in children received oseltamivir therapy within 48 h was not significantly shorter than that beyond 48 h (<italic>p</italic> &gt; 0.05). Additionally, percentages and severities of influenza-like symptoms, including headache, myalgia, fatigue, bellyache, vomiting, diarrhea, sore throat, cough, and coryza were not decreased and alleviated after treatment of oseltamivir.</p><p><bold>Conclusion:</bold> Oseltamivir treatment does not significantly shorten the duration of fever, nor does it significantly relieve influenza-like symptoms in children with infection of influenza.</p>