AUTHOR=Cheng Ziqian , Kang Chenglan , Che Songtian , Su Jingyun , Sun Qihan , Ge Tongtong , Guo Yi , Lv Jiayin , Sun Zhihui , Yang Wei , Li Bingjin , Li Xin , Cui Ranji TITLE=Berberine: A Promising Treatment for Neurodegenerative Diseases JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.845591 DOI=10.3389/fphar.2022.845591 ISSN=1663-9812 ABSTRACT=

Berberine, as a natural alkaloid compound, is characterized by a diversity of pharmacological effects. In recent years, many researches focused on the role of berberine in central nervous system diseases. Among them, the effect of berberine on neurodegenerative diseases has received widespread attention, for example Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and so on. Recent evidence suggests that berberine inhibits the production of neuroinflammation, oxidative, and endoplasmic reticulum stress. These effects can further reduce neuron damage and apoptosis. Although the current research has made some progress, its specific mechanism still needs to be further explored. This review provides an overview of berberine in neurodegenerative diseases and its related mechanisms, and also provides new ideas for future research on berberine.