AUTHOR=Bai Wenya , Huo Siying , Li Junjie , Shao Jianlin 

TITLE=Advances in the Study of the Ubiquitin-Editing Enzyme A20

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.845262

DOI=10.3389/fphar.2022.845262

ISSN=1663-9812

ABSTRACT=<p>Ubiquitin modification is a common post-translational protein modification and an important mechanism whereby the body regulates protein levels and functions. As a common enzyme associated with ubiquitin modification, the ubiquitin-editing enzyme A20 may be closely associated with the development of numerous pathological processes through its different structural domains. The aim of this paper is to provide an overview of the following: advances in ubiquitination research, the structure and function of A20, and the relationships between A20 and immune inflammatory response, apoptosis, necroptosis, pyroptosis, and autophagy.</p>