AUTHOR=Klapan Kim , Simon Dagmar , Karaulov Alexander , Gomzikova Marina , Rizvanov Albert , Yousefi Shida , Simon Hans-Uwe 

TITLE=Autophagy and Skin Diseases

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.844756

DOI=10.3389/fphar.2022.844756

ISSN=1663-9812

ABSTRACT=<p>Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles with their enzymes. Autophagy is widely known for its function in cellular homeostasis under physiological and pathological settings. Defects in autophagy have been implicated in the pathophysiology of a variety of human diseases. The new line of evidence suggests that autophagy is inextricably linked to skin disorders. This review summarizes the principles behind autophagy and highlights current findings of autophagy’s role in skin disorders and strategies for therapeutic modulation.</p>