AUTHOR=Deng Zhuo-fen , Bakunina Irina , Yu Hua , Han Jaehong , Dömling Alexander , Ferreira Maria-José U , Zhang Jian-ye 

TITLE=Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.815603

DOI=10.3389/fphar.2022.815603

ISSN=1663-9812

ABSTRACT=<p>Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR.</p>