AUTHOR=Singla Rajeev K. , Dhir Vivek , Madaan Reecha , Kumar Deepak , Singh Bola Simranjit , Bansal Monika , Kumar Suresh , Dubey Ankit Kumar , Singla Shailja , Shen Bairong 

TITLE=The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.769111

DOI=10.3389/fphar.2022.769111

ISSN=1663-9812

ABSTRACT=<p><bold>Ethnopharmacological relevance:</bold> The genus <italic>Alternanthera</italic> (<italic>Amaranthaceae</italic>) comprises 139 species including 14 species used traditionally for the treatment of various ailments such as hypertension, pain, inflammation, diabetes, cancer, microbial and mental disorders.</p><p><bold>Aim of the review:</bold> To search research gaps through critical assessment of pharmacological activities not performed to validate traditional claims of various species of <italic>Alternanthera.</italic> This review will aid natural product researchers in identifying <italic>Alternanthera</italic> species with therapeutic potential for future investigation.</p><p><bold>Materials and methods:</bold> Scattered raw data on ethnopharmacological, morphological, phytochemical, pharmacological, toxicological, and clinical studies of various species of the genus <italic>Alternanthera</italic> have been compiled utilizing search engines like SciFinder, Google Scholar, PubMed, Science Direct, and Open J-Gate for 100 years up to April 2021.</p><p><bold>Results:</bold> Few species of <italic>Alternanthera</italic> genus have been exhaustively investigated phytochemically, and about 129 chemical constituents related to different classes such as flavonoids, steroids, saponins, alkaloids, triterpenoids, glycosides, and phenolic compounds have been isolated from 9 species. Anticancer, antioxidant, antibacterial, CNS depressive, antidiabetic, analgesic, anti-inflammatory, and immunomodulator effects have been explored in the twelve species of the genus. A toxicity study has been conducted on 3 species and a clinical study on 2 species.</p><p><bold>Conclusions:</bold> The available literature on pharmacological studies of <italic>Alternanthera</italic> species reveals that few species have been selected based on ethnobotanical surveys for scientific validation of their traditional claims. But most of these studies have been conducted on uncharacterized and non-standardized crude extracts. A roadmap of research needs to be developed for the isolation of new bioactive compounds from <italic>Alternanthera</italic> species, which can emerge out as clinically potential medicines.</p>