AUTHOR=Liu Shuang , Jia Qiao-Jun , Peng Yi-Qing , Feng Ting-Hui , Hu Shu-Ting , Dong Juan-e , Liang Zong-Suo 

TITLE=Advances in Mechanism Research on Polygonatum in Prevention and Treatment of Diabetes

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.758501

DOI=10.3389/fphar.2022.758501

ISSN=1663-9812

ABSTRACT=<p>Diabetes mellitus is a fast-growing disease with a major influence on people’s quality of life. Oral hypoglycemic drugs and insulin are currently the main effective drugs in the treatment of diabetes, but chronic consumption of these drugs has certain side effects. Polysaccharides, saponins, flavonoids, and phenolics are the primary secondary metabolites isolated from the rhizomes of <italic>Polygonatum sibiricum</italic> Redouté [Asparagaceae], <italic>Polygonatum kingianum</italic> Collett &amp; Hemsl [Asparagaceae], or <italic>Polygonatum cyrtonema</italic> Hua [Asparagaceae], which have attracted much more attention owing to their unique therapeutic role in the treatment and prevention of diabetes. However, the research on the mechanism of these three <italic>Polygonatum</italic> spp. in diabetes has not been reviewed. This review provides a summary of the research progress of three <italic>Polygonatum</italic> spp. on diabetes and its complications, reveals the potential antidiabetic mechanism of three <italic>Polygonatum</italic> spp., and discusses the effect of different processed products of three <italic>Polygonatum</italic> spp. in treating diabetes, for the sake of a thorough understanding of its effects on the prevention and treatment of diabetes and diabetes complications.</p>