AUTHOR=Olvany Jasmine M. , Williams Scott M. , Zimmerman Peter A. 

TITLE=Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.752314

DOI=10.3389/fphar.2022.752314

ISSN=1663-9812

ABSTRACT=<p>Clinical trial and individual patient treatment outcomes have produced accumulating evidence that effective primaquine (PQ) treatment of <italic>Plasmodium vivax</italic> and <italic>P. ovale</italic> liver stage hypnozoites is associated with genetic variation in the human cytochrome P450 gene, <italic>CYP2D6</italic>. Successful PQ treatment of individual and population-wide infections by the <italic>Plasmodium</italic> species that generate these dormant liver stage forms is likely to be necessary to reach elimination of malaria caused by these parasites globally. Optimizing safe and effective PQ treatment will require coordination of efforts between the malaria and pharmacogenomics research communities.</p>