AUTHOR=Xian Bo Shang , Chen Wang , Chang Liu , Hao Ran Yu , Hui Hui Guo , Ya Kun Zhu , Wu Kun Xie , Hai Tao Fan , Wen Dan Cheng TITLE=The Research Progress of Exosomes in Osteoarthritis, With Particular Emphasis on the Therapeutic Effect JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.731756 DOI=10.3389/fphar.2022.731756 ISSN=1663-9812 ABSTRACT=

Exosomes participate in many physiological and pathological processes by regulating cell-to-cell communication. This affects the etiology and development of diseases, such as osteoarthritis (OA). Although exosomes in the OA tissue microenvironment are involved in the progression of OA, exosomes derived from therapeutic cells represent a new therapeutic strategy for OA treatment. Recent studies have shown that exosomes participate in OA treatment by regulating the proliferation, apoptosis, inflammation, and extracellular matrix synthesis of chondrocytes. However, studies in this field are scant. This review summarizes the therapeutic properties of exosomes on chondrocytes in OA and their underlying molecular mechanisms. We also discuss the challenges and prospects of exosome-based OA treatment.