Yanzhu Zhu
Fatma M. El-Demerdash
Xu Yang
Alex Boye
Michel Mansur Machado
Xinwei Li- 1Jilin Agriculture Science and Technology College, Jilin, Jilin Province, China
- 2Environmental Studies Department, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
- 3College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan Province, China
- 4Department of Medical Laboratory Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana
- 5Universidade Federal do Pampa, Uruguaiana, Brazil
- 6Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, China
Editorial on the Research Topic
Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, Volume II
Pollutants such as copper (Cu), cadmium (Cd), iron oxide nanoparticles (IONPs), and cyclophosphamide (CTX) exert toxicity on all animal species in the ecosystem (Gioia et al., 2011). Cu is an essential trace element in various cellular processes, but excessive levels of Cu are markedly harmful. Cd can exert toxic effects on various microorganisms, plants, and animals in very low quantities. As the first generation of nanomaterials, IONPs can cure iron deficiency in chronic kidney disease. CTX induces immunosuppression; however, the underlying mechanisms of these pollutants need to be further explored.
Quercetin (Que), Panax ginseng C. A. Meyer (PG), Tamarindus indica (TM), coenzyme Q10 (CoQ), strontium (Sr), and selenium-enriched yeast (SeY) have the potential to be used in the treatment of the toxicity. Que is a special subclass of flavonoid and a powerful antioxidant. PG has a variety of ginsenosides that show diverse biological effects on various diseases. As a traditional medicine, TM has anti-inflammatory and analgesic effects. CoQ10 plays a key role in mitochondrial bioenergetics and exerts a natural antioxidant effect. Selenium is a micronutrient that is essential for the proper functioning of all organisms. High doses of Sr induce alterations in mineralization.
Many researchers have focused on this field and have obtained important findings. Habotta et al. reported that SeY reduces the hepatic and renal damage induced by Cu in broiler chickens, and it can be used as a potential feed supplement (Wang et al.). Wang et al. found that ginsenosides alleviate exogenous toxicity and reduce drug toxicities and they could potentially be used as a treatment for toxicity (Han et al.). Han et al. revealed that IONPs accumulated in the macrophage lysosomes and the spleen eliminate the IONPs in the systemic circulation (Attia et al.). Attia et al. found that Cd damages the adipocyte function (Huang et al.). Attia et al. found that Que could alleviate kidney damage and renal-cell apoptosis induced by Cd (Wang et al.). Wang et al. found that QE has an antioxidant effect in BRL-3A cells (Abdelnaby et al.). Abdelnaby et al. found that hepatorenal damage induced by Cd is alleviated by TM or CoQ supplementation (Zheng et al.). Zheng et al. found that immunosuppression in mice induced by CTX could be treated by ginsenoside Rb2 (Liu et al.). Liu et al. found that primary chondrocyte proliferation is promoted by Sr, but primary chondrocyte differentiation is inhibited by Sr (Liu et al.).
This special issue provides new ideas for the application of Que, PG, TM, CoQ, SeY, and Sr in the prevention and treatment of Cu, Cr, IONPs, and CTX toxicity.
Author contributions
YZ, FE, XY, AB, MM, and XL contributed to this topic.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Keywords: toxicity mechanisms, toxicity exposure, toxicokinetic, risk assessment, metals
Citation: Zhu Y, El-Demerdash FM, Yang X, Boye A, Machado MM and Li X (2023) Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, Volume II. Front. Pharmacol. 13:1107327. doi: 10.3389/fphar.2022.1107327
Received: 24 November 2022; Accepted: 21 December 2022;
Published: 11 January 2023.
Edited and reviewed by:
Ursula Gundert-Remy, Charité Universitätsmedizin Berlin, GermanyCopyright © 2023 Zhu, El-Demerdash, Yang, Boye, Machado and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yanzhu Zhu, zyzzu@126.com
†ORCID:Yanzhu Zhu, orcid.org/0000-0001-6770-6372; Fatma M. El-Demerdash, orcid.org/0000-0001-5624-9145; Xu Yang, orcid.org/0000-0002-5740-9945; Alex Boye, orcid.org/0000-0002-1133-0940; Michel Mansur Machado, orcid.org/0000-0002-7583-9332