AUTHOR=Peng Haoyuan , Zhong Lei , Cheng Lin , Chen Lu , Tong Rongsheng , Shi Jianyou , Bai Lan 

TITLE=Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1094405

DOI=10.3389/fphar.2022.1094405

ISSN=1663-9812

ABSTRACT=<p><italic>Ganoderma lucidum (G. lucidum, Lingzhi)</italic> is a well-known herbal medicine with a variety of pharmacological effects. Studies have found that <italic>G. lucidum</italic> has pharmacological effects such as antioxidant, antitumor, anti-aging, anti-liver fibrosis, and immunomodulation. The main active components of <italic>G. lucidum</italic> include triterpenoids, polysaccharides, sterols, peptides and other bioactive components. Among them, the triterpenoids and polysaccharide components of <italic>G. lucidum</italic> have a wide range of anti-liver fibrotic effects. Currently, there have been more reviews and studies on the antioxidant, antitumor, and anti-aging properties of <italic>G. lucidum</italic>. Based on the current trend of increasing number of liver fibrosis patients in the world, we summarized the role of <italic>G.lucidum</italic> extract in anti-liver fibrosis and the effect of <italic>G. lucidum</italic> extract on liver fibrosis induced by different pathogenesis, which were discussed and analyzed. Research and development ideas and references are provided for the subsequent application of <italic>G. lucidum</italic> extracts in anti-liver fibrosis treatment.</p>