AUTHOR=Zhou Daoying , Duan Zhen , Li Zhenyu , Ge Fangfang , Wei Ran , Kong Lingsuo 

TITLE=The significance of glycolysis in tumor progression and its relationship with the tumor microenvironment

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1091779

DOI=10.3389/fphar.2022.1091779

ISSN=1663-9812

ABSTRACT=Glycolysis is a known modulator of tumorigenesis and tumor development. The tumor microenvironment (TME) is a complex niche whereby tumor cells survive and develop, and it constantly interacts and co-evolves with other tumor cells. In recent years, there is a renewed interest in glycolysis and TME. This review discussed the significance of glycolysis in tumor development, its association with the TME, and potential glycolysis-targeted therapies, in order to provide new ideas for clinical tumor treatments.