AUTHOR=Zhang Yu , Gao Hui , Zhang Yu , Shao Yue-Ming , Zhang Rui-Hua , Wen Xiao-Yu 

TITLE=Correlation between serum cytokines and clinicopathological features in patients with drug-induced liver injury

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1070802

DOI=10.3389/fphar.2022.1070802

ISSN=1663-9812

ABSTRACT=<p><bold>Objectives:</bold> Changes in serum levels of cytokines have been proposed as possible biological markers of tissue damage, including drug-induced liver injury (DILI). Here, we aimed to screen cytokine markers that have guiding significance for the degree of inflammation of DILI.</p><p><bold>Patients and methods:</bold> 54 patients with DILI were retrospectively analyzed as the experimental group, and 14 healthy subjects were randomly selected as the control group. A total of 20 cytokines were detected by using a cytokine protein antibody chip, and differentially expressed proteins were screened.</p><p><bold>Results:</bold> There were significant differences in serum cytokines between DILI patients and healthy controls. Compared with the control group, the DILI group expressed 11 differential proteins. IL-8, TNF RII, TNFα, TNF RI, MIP-1β, MIP-1α, and IL-1β were differentially expressed in DILI patients with different degrees of inflammation from G1 to G4. MIG, IL-12p40, and IL-10 were differentially expressed in the higher degree of inflammation groups (G2, G3, and G4 groups). Tissue inhibitor of metalloproteinases-1 (TIMP-1) was differentially expressed in the group with the highest inflammation degree (G4 group). Chemokine C-C motif ligand 1 (I-309) was only differentially expressed in the lowest inflammation group (G1 group).</p><p><bold>Conclusion:</bold> The changes and differential expression of specific cytokine levels were helpful for evaluating different degrees of inflammation of DILI.</p>