AUTHOR=Li Minghui , Zhang Wen , Xu Xiaopeng , Liu Guoying , Dong Mengfei , Sun Kaoxiang , Zhang Peng 

TITLE=Nanosystems for chemodynamic based combination therapy: Strategies and recent advances

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1065438

DOI=10.3389/fphar.2022.1065438

ISSN=1663-9812

ABSTRACT=<p>Chemodynamic therapy (CDT), a newly developed approach for cancer treatment, can convert hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) into toxic hydroxyl radicals (•OH) by using Fenton/Fenton-like reaction to kill tumor cells. However, due to the complexity of the intracellular environment of tumor cells, the therapeutic efficacy of CDT was severely restricted. Recently, combination therapy strategies have become popular approaches for tumor treatment, and there are numerous studies have demonstrated that the CDT-based combination strategies can significantly improve the anti-tumor efficiency of CDT. In this review, we outline some of the recent progress in cancer chemodynamic therapy from 2020, and discuss the progress in the design of nanosystems for CDT synergistic combination therapies.</p>