AUTHOR=Sun Kai , Li Chenyuan , Liao Shichong , Yao Xinrui , Ouyang Yang , Liu Yi , Wang Zhong , Li Zhiyu , Yao Feng TITLE=Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1043344 DOI=10.3389/fphar.2022.1043344 ISSN=1663-9812 ABSTRACT=

Ferritinophagy, a form of autophagy, is also an important part of ferroptosis, a type of regulated cell death resulting from abnormal iron metabolism involving the production of reactive oxygen species. As ferroptosis, autophagy and cancer have been revealed, ferritinophagy has attracted increasing attention in cancer development. In this review, we discuss the latest research progress on ferroptosis, autophagy-associated ferroptosis led by ferritinophagy, the regulators of ferritinophagy and promising cancer treatments that target ferritinophagy. Ferritinophagy is at the intersection of ferroptosis and autophagy and plays a significant role in cancer development. The discussed studies provide new insights into the mechanisms of ferritinophagy and promising related treatments for cancer.